Genetic diversity of small-ruminant lentiviruses: characterization of Norwegian isolates of Caprine arthritis encephalitis virus

Genetic diversity of small-ruminant lentiviruses: characterization of Norwegian isolates of Caprine arthritis encephalitis virus.

Small-ruminant lentiviruses (SRLVs), including Caprine arthritis encephalitis virus (CAEV) in goats and maedi-visna virus (MVV) in sheep, are lentiviruses that, despite overall similarities, show considerable genetic variation in regions of the SRLV genome. To gain further knowledge about the genetic diversity and phylogenetic relationships among field isolates of SRLVs occurring in geographica...

Caprine Arthritis-Encephalitis, Small Ruminant Lentivius Infection

Importance Caprine arthritis and encephalitis (CAE) is an economically important viral disease of goats. The caprine arthritis encephalitis virus (CAEV), a lentivirus; infects its hosts for life. Although most infections are subclinical, a minority of animals develops progressive, untreatable disease syndromes including polyarthritis in adults and encephalomyelitis in kids. This virus also caus...

Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system.

The small-ruminant lentiviruses ovine maedi-visna virus (MVV) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthritis, and mastitis in sheep and goats. Icelandic MVV strains, which are lytic in tissue culture, have a wide species distribution of functional receptors, which includes human cells. In contrast, functional receptors for the nonlytic CAEV ...

Virus Pseudotype System Selectable Caprine Arthritis- Encephalitis Cytopathic Variants Determined with a Host Range of Small-Ruminant Lentivirus

Immunization against Small Ruminant Lentiviruses

Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies inv...